STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus. Remmers EF*, Plenge RM*, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PIW, Le JM, Lee H, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, and Gregersen PK New Eng J Med. 2007 Sep 6;357(10):977-86. PMID: 17804842 *contributed equally
This represents one of the first large-scale genetic studies demonstrating that common alleles influence risk of two distinct autoimmune diseases (RA and SLE). We used Tagger to impute the associated STAT4 variant.